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Thursday, 07/11/2019

Nature publication on the functional architecture of mitochondria

Congratulations to the authors, esp. to our IRTG members Florian & Martin!

Our IRTG members Prof. Martin van der Laan and our associated trainee Florian Wollweber (both from the Dept. of Medical Biochemistry & Molecular Biology, UdS, Homburg) have made an important contribution to the decoding of the structural design of mitochondria. The study was conducted in a cooperation project with the Max Delbrück Center (MDC) for Molecular Medicine in Berlin and the Max Planck Institute (MPI) for Biophysics in Frankfurt. The consortium of structural biologists and biochemists succeeded in unraveling the function of two key proteins involved in the vital transformation processes of mitochondria. The results of the study were published in the renowned scientific journal Nature and will likely support the development of new therapies for mitochondrial diseases in the future.

Faelber K, Dietrich L, Noel JK, Wollweber F, Pfitzner A-K, Mühleip A, Sánchez R, Kudryashev M, Chiaruttini N,  Lilie H, Schlegel J, Rosenbaum E, Hessenberger M, Matthaeus C,  Kunz S, von der Malsburg A, Noé F,  Roux A,  van der Laan M, Kühlbrandt W & Daumke O (2019) Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature, DOI 10.1038/s41586-019-1372-3