Publications

2020

  • Chitirala P, Ravichandran K, Schirra C, Chang H-F, Krause E, Kazmaier U, Lauterbach MA & Rettig J (2020) Role of V-ATPase a3-Subunit in Mouse CTL Function. J. Immunol. ji1901536 DOI: https://doi.org/10.4049/jimmunol.1901536

  • Duscha K, Martins Rodrigues C, Müller M, Wartenberg R, Fliegel L, Deitmer JW, Jung M, Zimmermann R & Neuhaus HE (2020) 14-3-3 proteins and other candidates form protein-protein interactions with the cytosolic C-terminal end of SOS1 affecting its transport activity. Int. J. Mol. Sci., accepted

  • Klein MC, Lerner M, Nguyen D, Pfeffer S, Dudek J, Förster F, Helms V, Lang S & Zimmermann R (2020) TRAM1 protein may support ER protein import by modulating the phospholipid bilayer near the lateral gate of the Sec61 channel, Channels 14, 28-44
  • Li X, Dutta D, Jung M, Zimmermann R & Fliegel L (2020) Amino Acids 563–566 of the Na+/H+ Exchanger Isoform 1 C-Terminal Cytosolic Tail Prevent Protein Degradation and Stabilize Protein Expression and Activity. Int. J. Mol. Sci. 2020, 21(5), 1737.
    https://doi.org/10.3390/ijms21051737
  • Sarder HAM, Li X, Funaya Ch, Cordat E, Schmitt M & Becker B (2020) Saccharomyces cerevisiae: First steps to a suitable model system to study the function and intracellular transport of the human kidney anion exchanger 1, mSphere 00802-19. https://msphere.asm.org/content/5/1/e00802-19
  • Schorr S, Nguyen D, Haßdenteufel S, Nagaraj N, Cavalié A, Greiner M, Weissgerber P, Loi M, Paton AW, Paton JC, Molinari M, Förster F, Dudek J, Lang S, Helms V & Zimmermann R (2020) Proteomics identifies signal peptide features determining the substrate specificity in human Sec62/Sec63-dependent ER protein import“, in press in FEBS J. doi: 10.1111/febs.15274
  • Van Nieuwenhove E, Barber JS, Neumann J, Smeets E, Willemsen M, Pasciuto E, Prezzemolo T, Lagou V, Seldeslachts L, Malengier-Devlies B, Metzemaekers M, Haßdenteufel S, Kerstens A, Van der Kant R, Rousseau F, Schymkowitz J, Di Marino D, Lang S, Zimmermann R, Schlenner S, Munck S, Proost P, Matthys P, Devalck C, Boeckx N, Claessens F, Wouters C, Humblet-Baron S & Meyts I, Liston A (2020) Defective Sec61α1 underlies a novel cause of autosomal dominant severe congenital neutropenia. Im Press, https://doi.org/10.1016/j.jaci.2020.03.034
  • Vu DP, Rodrigues CM, Jung B, Meissner G, Klemens PAW, Holtgräwe D, Fürtauer L, Nägele T, Nieberl P, Pommerrenig B, Neuhaus HE (2020) Vacuolar sucrose homeostasis is critical for development, seed properties and survival of dark phases of Arabidopsis. Exp. Bot., accepted
  • Zimmermann R & Lang S (2020) A Little AXER ABC: ATP, BiP, and Calcium Form a Triumvirate Orchestrating Energy Homeostasis of the Endoplasmic Reticulum. Sagepub. 3: 1-12 https://doi.org/10.1177/2515256420926795

 

 

2019

  • August A, Schmidt N, Klingler J, Baumkötter F, Lechner M, Klement J, Eggert S, Vargas C, Wild K, Keller S & Kins S (2019) Copper and zinc ions govern the trans-directed dimerization of APP family members in multiple ways.  J. Neurochem. 151, 625-641
  • Backes S, Garg SG, Becker L, Peleh V, Glockshuber R, Gould SB & Herrmann JM (2019) Development of the mitochondrial intermembrane space disulfide relay represents a critical step in eukaryotic evolution. Mol Biol Evol. 36, 742-756
  • Beggs MR, Lee JJ, Busch K, Raza A, Dimke H, Weissgerber P, Engel J, Flockerzi V, Alexander RT
    (2019) TRPV6 and Cav1.3 Mediate Distal Small Intestine Calcium Absorption Before Weaning. Cell Mol Gastroenterol Hepatol 2-345X(19)30092-X DOI:10.1016/j.jcmgh.2019.07.005
  • Blum A, Khalifa S, Nordström K, Simon M, Schulz MH & Schmitt MJ (2019) Transcriptomics of a KDELR1 knockout cell line reveals modulated cell adhesion properties. Scientific Reports 9: 10611. DOI 10.1038/s41598-019-47027-5
  • Boos F, Krämer L, Groh C, Jung F, Haberkant P, Stein F, Wollweber F, Gackstatter A, Zöller E, van der Laan M, Savitski MM, Benes V & Herrmann JM (2019). Mitochondrial protein-induced stress triggers a global adaptive transcriptional programme. Nature Cell Biol 21: 442-451
  • Chitirala P, Ravichandran K, Galgano D, Sleiman M, Krause E, Bryceson Y & Jens Rettig (2019) Cytotoxic granule exocytosis from human cytotoxic T lymphocytes is mediated by VAMP7. Front. Immunol. DOI 10.3389/fimmu.2019.01855
  • Danielczak B, Meister A & Keller S (2019) Influence of Mg2+ and Ca2+ on nanodisc formation by diisobutylene/maleic acid (DIBMA) copolymer. Chem. Phys. Lipids , 221, 30-38
  • Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK & Chae PS (2019) Self-assembly behaviors and application of terphenyl-cored trimaltosides for membrane protein study: impact of detergent hydrophobic group geometry on protein stability. Chem. Eur. J. 25, 11545-11554
  • Faelber K, Dietrich L, Noel JK, Wollweber F, Pfitzner A-K, Mühleip A, Sánchez R, Kudryashev M, Chiaruttini N,  Lilie H, Schlegel J, Rosenbaum E, Hessenberger M, Matthaeus C,  Kunz S, von der Malsburg A, Noé F,  Roux A,  van der Laan M, Kühlbrandt W & Daumke O (2019) Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1. Nature, DOI 10.1038/s41586-019-1372-3
  • Gamayun I, 0´Keefe S, Pick T, Klein MC, Nguyen D, McKibbin C, Piacenti M, Williams HM, Flitch SL, Whitehead RC, Swanton L, Helms V, High S, Zimmermann R & Cavalié A (2019) Eeyarestatin compounds selectively enhance Sec61-mediated Ca2+ leakage from the endoplasmic reticulum“, Cell Chem. Biol. 26, 1-13. doi.org/10.1016/j.chembiol.2019.01.10

  • Haßdenteufel S, Nguyen D, Helms V, Lang S & Zimmermann R (2019) ER import of small human presecretory proteins: components and mechanisms. FEBS Letters 593: 2506-2524 DOI 10.1002/1873-3468.13542
  • Lashhab R, Rumley AC, Arutyunov D, Rizvi M, You C, Dimke H, Touret N, Zimmermann R, Jung M, Chen X-Z, Alexander T & Cordat E (2019) The kidney anion exchanger 1 affects tight junction properties via claudin-4. Scientific Reports 9: 3099 (https://www.nature.com/articles/s41598-019-39430-9)
  • Laborenz J, Hansen KG, Prescianotto-Baschong C, Spang A, Herrmann JM (2019) In vitro import experiments with semi-intact cells suggest a role of the Sec61 paralog Ssh1 in mitochondrial biogenesis. Biol Chem 400: 1229-1240 DOI: 10.1515/hsz-2019-0196
  • Lang I, Jung M, Niemeyer BA, Ruth P & Engel J (2019) Expression of the LRRC52 γ subunit (y2) may provide Ca2+-independent activation of BK currents in mouse inner hair cells. FASEB J. DOI 10.1096/fj.201900701RR
  • Lang S, Hilsabeck TA, Wilson KA, Sharma A, Bose N, Brackman DJ, Beck JN, Chen L, Watson MA, Killilea DW, Ho S, Kahn A, Giacomini K, Stoller ML, Chi T & Kapahi P (2019) A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster. PLOS Genetics 15: e1008318 DOi 10.1371/journal.pgen.1008318
  • Malhotra D, Jung M, Fecher-Trost C, Lovatt M, Peh GSL, Noskov S, Mehta JS, Zimmermann R & Casey JR (2019) Defective cell adhesion function of solute transporter, SLC4A11, in endothelial corneal dystrophies. Human Molecular Genetics, ddz259, https://doi.org/10.1093/hmg/ddz259
  • Ohler L, Niopek-Witz S, Mainguet SE & Möhlmann T (2019) Pyrimidine salvage: physiological functions and interaction with chloroplast biogenesis. Plant Physiology, DOI: https://doi.org/10.1104/pp.19.00329
  • Patzke K, Prananingrum P, Klemens PAW, Trentmann O, Martins Rodrigues C, Keller I, Fernie AR, Geigenberger P, Bölter B, Lehmann M, Schmitz-Esser C, Pommerrenig B, Haferkamp I & Neuhaus HE (2019) The plastidic sugar transporter pSuT influences flowering and affects cold responses. Plant Physiol.179, 569-587
  • Ziska A, Tatzelt J, Dudek J, Paton AW, Paton JC, Zimmermann R & Haßdenteufel S (2019) The signal peptide plus a cluster of positive charges in prion protein dictate chaperone-mediated Sec61-channel gating, Biol. Open 8, bio040691. Doi: 10.1242/bio.040691

2018

  • Backes CS, Friedmann KS, Mang S, Knörck A, Hoth M & Kummerow C (2018) Natural killer cells induce distinct modes of cancer cell death: Discrimination, quantification, and modulation of apoptosis, necrosis, and mixed forms. J Biol Chem. 19;293(42):16348-16363. doi: 10.1074/jbc.RA118.004549
  • Belkacemi A, Hui X, Wardas B, Laschke MW, Wissenbach U, Menger MD, Lipp P, Beck A & Flockerzi V (2018) IP3 Receptor-Dependent Cytoplasmic Ca2+ Signals Are Tightly Controlled by Cavβ3. Cell Reports, 22: 1339-1349
  • Chang HF, Mannebach S, Beck A, Ravichandran K, Krause E, Frohnweiler K, Fecher-Trost C, Schirra C,  Pattu V, Flockerzi V & Rettig J (2018) Cytotoxic granule exocytosis depends on the Flower protein. Jcb. 217(2):667-683/jcb.201706053. doi:10.1007/978-1-4939-6881-7_11. PMID: 28255702
  • Danielczak B, Grethen A, Vargas C, & Keller S (2018) Nanotechnologie für die Membranprotein-Forschung. LABO 2018, 1-2/2018, 61–64

  • Danielczak B & Keller S (2018) Collisional lipid exchange among DIBMA-encapsulated nanodiscs (DIBMALPs). Eur. Polym. J., accepted
  • Daumann M, Hickl D, Zimmer D, De Tar RA, Kunz HH & Möhlmann T (2018) Characterization of filament-forming CTP synthases from Arabidopsis thaliana. Plant J., epub ahead of print; doi 10.1111/tpj.14032
  • Forero-Quintero LS, Ames S, Schneider HP, Thyssen A, Boone CD, Andring JT, McKenna R, Casey JR, Deitmer JW & Becker HM (2018) Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70. J. Biol. Chem. (DOI: 10.1074/jbc.RA118.005536)
  • Graus D, Konrad KR, Bemm F, Nebioglu MGP, Lorey C, Duscha K, Güthoff T, Herrmann J, Ferjani A, Cuin TA, Roelfsema MRG, Schumacher K, Neuhaus HE, Marten I & Hedrich R (2018) High V-PPase activity is beneficial under high salt loads, but detrimental without salinity. New Phytol. 219, 1421-1432
  • Grethen A, Glueck D & Keller S (2018) Role of Coulombic repulsion in collisional lipid transfer among SMA (2:1)-bounded nanodiscs. J. Membr. Biol. 251, 443-451. PubMed
  • Hansen KG, Aviram N, Laborenz J, Bibi C, Meyer M, Spang A, Schuldiner M & Hermann JM (2018) ER surface retrieval pathway safe-guards the import of mitochondrial membrane proteins in yeast. Science 361: 1118-1122
  • Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S & Zimmerman R (2018) Chaperone-mediated Sec61 channel gating during ER import of small precursor proteins overcomes Sec61 inhibitor-reinforced energy barrier. Cell Reports 23, 1373–1386
  • Klein MC, Zimmermann K, Schorr S, Landini M, Klemens PAW, Altensell J, Jung M, Krause E, Nguyen D, Helms V, Rettig J, Fecher-Trost C, Cavalié A, Hoth M, Bogeski I, Neuhaus HE, Zimmermann R, Lang S & Haferkamp I (2018) AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticululum. Nat. Commun. 9: 3489
  • Könnel A, Bugaeva W, Gügel IL & Philippar K (2018) BANFF: bending of bilayer membranes by amphiphilic α-helices is necessary for form and function of organelles Biochem Cell Biol. https://doi.org/10.1139/bcb-2018-0150
  • Nguyen D, Stutz R, Schorr S, Lang S, Pfeffer S, Freeze HH, Förster F, Helms V, Dudek J, Zimmermann R (2018) Proteomics reveals signal peptide features determining the client specificity in human TRAP-dependent ER protein import.  Nat. Commun. (DOI: 10.1038/s41467-018-06188-z)
  • Oestreicher J, Morgan B (2018) Glutathione: subcellular distribution and membrane transport. Biochemistry and Cell Biology
    [Epub ahead of print]
  • Rampelt H, Wollweber F, Gerke C, de Boer R, van der Klei I, Bohnert M, Pfanner N & van der Laan M (2018) Assembly of the mitochondrial cristae organizer Mic10 is regulated by Mic26-Mic27 antagonism and cardiolipin. J. Mol. Biol. 430, 1883-1890
  • Schmid LM, Ohler L, Möhlmann T, Brachmann A, Muino JM, Leister D, Meurer J & Manavski N (2018) PUMPKIN, the sole plastid UMP kinase, associates with group II introns and alters their metabolism. Plant Phys., 179, 248-264
  • Schubert D,  Klein MCHassdenteufel S,  Caballero-Oteyza A,  Yang L, Proietti M,  Bulashevska A,  Kemming J, Kühn J, Winzer S,  Rusch S,  Fliegauf M, Schäffer AA,  Pfeffer S, Geiger R, Cavalié A, Cao H, Yang F, Li Y, Rizzi M, Eibel H, Kobbe R, Marks AL, Peppers BP, Hostoffer RW, Puck JM, Zimmermann R &  Grimbacher B (2018) Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1). Journal of Allergy and Clinical Immunology 141, 1427-1438
  • Zheng W, Yang X, Hu R, Cai R, Hofmann L, Wang Z, Hu Q, Liu X, Bulkey D, Yu Y, Tang J, Flockerzi V, Cao Y, Cao E & Chen XZ (2018) Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nature Communications. 9: 2302
  • Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, Fatehi M, Liu X, Hussein S, Kong T, Li J, Light PE, Tang J, Flockerzi V, Tsiokas L & Chen X-Z (2018) Direct binding between Pre-S1 and TRP-like domains in TRPP channels mediates gating and functional regulation by PIP2. Cell Reports, 22:1560-1573
  • Zhou X, Friedmann KS, Lyrmann H, Zhou Y, Schoppmeyer R, Knörck A, Mang S, Hoxha C, Angenendt A, Backes CS, Mangerich C, Zhao R, Cappello S, Schwär G, Hässig C, Neef M, Bufe B, Zufall F, Kruse K, Niemeyer BA, Lis A, Qu B, Kummerow C, Schwarz EC & Hoth M (2018) A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity. J Physiol. doi: 10.1113/JP274964

2017

  • Alexander RT, McArthur E, Jandoc R, Welk B, Hayward JS, Jain AK, Braam B, Flockerzi V, Garg AX & Ross Quinn R, (2017) Antihypertensive medications and the risk of kidney stones in older adults: a retrospective cohort study, Hypertension Research 40, 837–842
  • Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, Beck A (2017) TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo. Wiley Glia 65: 1535-1549
  • Chang HF, Mannebach S, Beck A, Ravichandran K, Krause E, Frohnweiler K, FecherTrost C, Schirra C, Pattu V, Flockerzi V & Rettig J (2017) Cytotoxic granule endocytosis depends on the flower protein, Jcb, 217:667-683
  • Cuevas Arenas R, Danielczak B, Martel A, Porcar L, Breyton C, Ebel C & Keller S (2017) Fast collisional lipid transfer among polymer-bounded nanodiscs. Sci. Rep. 7, 45875 PubMed
  • Erdogan AJ & Riemer J (2017) Mitochondrial disulfide relay and its substrates: mechanisms in health and disease. Cell Tissue Res 367: 59–72
  • Forero-Quintero LS, Deitmer JW & Becker HM (2017) Reduction of epileptiform activity in ketogenic mice: The role of monocarboxylate transporters. Sci Rep 7:4900 (doi: 10.1038/s41598-017-05054-0)
  • Friederich MW, Erdogan AJ, Coughlin CR, Elos MT, Jiang H, O’Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK & Riemer J (2017) Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Human Molecular Genetics 26: 702–716 (doi: 10.1093/hmg/ddw431)
  • Grethen A, Oluwole AO, Danielczak B, Vargas C & Keller S (2017) Thermodynamics of nanodisc formation mediated by styrene/maleic acid (2:1) copolymer. Sci. Rep. 7: 11517
  • Haßdenteufel S, Sicking M, Schorr S, Aviram N, Fecher-Trost C, Schuldiner M, Jung M, Zimmermann R & Lang S (2017) hSnd2 protein represents an alternative targeting factor to the endoplasmic reticulum in human cells. FEBS Letters 591, 3211-3224
  • Hofmann L, Wang H, Beck A, Wissenbach U, Flockerzi V (2017) A conserved gating element in TRPV6 channels. Cell Calcium: 63: 24-28
  • Hofmann L, Wang H, Zheng W, Philipp SE, Hidalgo P, Cavalié A, Chen XZ, Beck A, Flockerzi V (2017) The S4-S5 linker - gearbox of TRP channel gating. Cell Calcium, 67:156-165
  • Lang S, Pfeffer S, Lee PH, Cavalié A, Helms V, Förster F & Zimmermann R (2017) An Update on Sec61 Channel Functions, Mechanisms, and Related Diseases. Frontiers in Physiology 8: 887
  • Oluwole AO, Danielczak B, Meister A, Babalola JO, Vargas C & Keller S (2017) Solubilization of membrane proteins into functional lipid-bilayer nanodiscs by diisobutylene/maleic acid copolymer. Angew. Chem. Int. 56, 1919–1924. PubMed
  • Oluwole AO, Klingler J, Danielczak B, Babalola JO, Vargas C, Pabst G & Keller S (2017) Formation of lipid-bilayer nanodiscs by diisobutylene/maleic acid (DIBMA) copolymer. Langmuir 33, 14378–14388. PubMed
  • Peckys DB, Stoerger C, Latta L, Wissenbach U, Flockerzi V, de Jonge N (2017) The stoichiometry of the TMEM16A ion channel determined in intact plasma membranes of COS-7 cells using liquid-phase electron microscopy. J Struct Biol: 199: 102-113 (doi: 10.1016/j.jsb.2017.05.009)
  • Peleh V, Zannini F, Backes S, Rouhier N, Herrmann JM (2017) Erv1 of Arabidopsis thaliana can directly oxidize mitochondrial intermembrane space proteins in the absence of redox-active Mia40. BMC Biology 15: 106
  • Rangl M, Rima L, Klement J, Miyagi A, Keller S & Scheuring S (2017) Real-time visualization of phospholipid degradation by outer membrane phospholipase A using high-speed atomic force microscopy. J. Mol. Biol. 429: 977–986
  • Suzuki S, Schwartz SL, Mueller NC, Schmitt MJ (2017) Cysteine residues in a yeast viral A/B toxin crucially control host cell killing via pH-triggered disulfide rearrangements. Mol Biol Cell 28: 1123-1131
  • Ure ME, Heydari E, Pan W, Ramesh A, Rehman S, Morgan C, Pinsk M, Erickson R, Herrmann JM, Dimke H, Cordat E, Lemaire M, Walter M & Alexander RT (2017) A variant in a Cis-regulatory element enhances claudin-14 expression and is associated with pediatric-onset hypercalciuria and kidney stones. Hum Mutat 38: 649-657 (doi: 10.1002/humu.23202)
  • Wollweber F, von der Malsburg K & van der Laan M (2017) Mitochondrial contact site and cristae organizing system: A central player in membrane shaping and crosstalk. Biochim Biophys Acta 1864:1481-1489 (doi:10.1016/j.bbamcr.2017.05.004)
  • Zheng W, Hu R, Cai R, Hofmann L, Hu Q, Fatehi M, Long W, Kong T, Tang J, Light P, Flockerzi V, Cao Y, Chen XZ (2017) Identification and characterization of hydrophobic gate residues in TRP channels. PubMed, 32:639-653

2016

  • Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS & Schuldiner M (2016) The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature 540: 134-138
  • Becker B, Blum A, Gießelmann E, Dausend J, Rammo D, Müller NC, Tschacksch E, Steimer M, Spindler J, Becherer U, Rettig J, Breinig F, Schmitt MJ (2016) H/KDEL receptors mediate host cell intoxication by a viral A/B toxin in yeast. Sci Rep 6: 31105 (DOI: 10.1038/srep31105)
  • Chang HF, Bzeih H, Chitirala P, Ravichandran K, Sleiman M, Krause E, Hahn U, Pattu V & Rettig J (2016). Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes. Cell Mol Life Sci. PMID: 27585956
  • Chang HF, Bzeih H, Schirra C, Chitirala P, Halimani M, Cordat E, Krause E, Rettig J & Pattu V (2016). Endocytosis of Cytotoxic Granules Is Essential for Multiple Killing of Target Cells by T Lymphocytes. J Immunol. PMID: 27527597
  • Fumagalli F, Noack J, Bergmann T, Cebollero E, Pisoni GB, Fasana E, Fregno I, Galli C, Loi M, Soldá T, D´Antuono R, Raimondi A, Jung M, Melnyk A, Schorr S, Schreiber A, Simonelli L, Varani L, Wilson-Zbinden C, Zerbe O, Hoffmann K, Peter M, Quadroni M, Zimmermann R & Molinari M (2016) Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery, Nature Cell Biol 18: 1173-1184 (doi: 10.1038/ncb3423)
  • Gimpl K, Klement J, Keller S (2016) Characterizing protein/detergent complexes by triple-detection size-exclusion chromatography.Biol. Proced. 18, 4
  • Panigrahi R, Arutyunova E, Panwar P, Gimpl K, Keller S & Lemieux MJ (2016) Reversible unfolding of rhomboid intramembrane proteases. Biophys J (in press)
  • Peleh V, Cordat E, Herrmann JM (2016) Mia40 is a trans-site receptor that drives protein import into the mitochondrial intermembrane space by hydrophobic substrate binding. eLive (DOI: 10.7554/eLife.16177)
  • Pertl-Obermexyer, Duscha K, Trentmann O, Neuhaus E & Schulze W (2016) Quantitation of vacuolar sugar transporter abundance changes using QconCAT synthtetic peptides. Front Plant Sci (in press)
  • Ramesh A, Peleh V, Martinez-Caballero S, Wollweber F, Sommer F, van der Laan M, Schroda M, Alexander RT, Campo ML & Herrmann JM (2016) A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import. J Cell Biol 214: 417-431. Published August 8, 2016, doi:10.1083/jcb.201602074
  • Zheng W, Yang J, Beauchamp E, Cai R, Hussein S, Hofmann L, Li Q, Flockerzi V, Berthiaume L G, Tang JF & Chen X Z (2016). Regulation of TRPP3 channel function by N-terminal domain palmitoylation and phosphorylation. JBC, 291:25678-25691

2015

  • Bangera M, Panigrahi R, Sagurthi SR, Savithri HS & Murthy MRN (2015) Structural and functional analysis of two universal stress proteins YdaA and YnaF from Salmonella typhimurium: possible roles in microbial stress tolerance. J Struc Biol 189: 238-250
  • Bode M, Wöllhaf M, Bohnert M, van der Laan M, Sommer F, Jung M, Zimmermann R, Schroda M & Herrmann JM (2015) Cox19 is a dynamic interaction partner of the copper-binding protein Cox11 in the intermembrane space of mitochondria. Mol Biol Cell 26: 2385-2401
  • Daumann M, Fischer M, Niopek-Witz S, Girke C and Möhlmann T (2015) Apoplastic Nucleoside Accumulation in Arabidopsis Leads to Reduced Photosynthetic Performance and Increased Susceptibility Against Botrytis cinerea. Front. Plant Sci. 6:1158
  • Friauf E, Fischer AU & Fuhr M (2015) Synaptic plasticity in the auditory system: a review. Cell Tissue Res 361:177-214
  • Frotscher E, Danielczak B, Vagas C, Meister A, Durand G, Keller S (2015) A fluorinated detergent for membrane-protein applications. Angew Chem Int Ed 54: 5069–5073
  • Girke C, Arutyunova E, Syed M, Traub M, Möhlmann T & Lemieux J (2015) High yield expression and purification of equilibrative nucleoside transporter 7 (ENT7) from Arabidopsis thaliana. Biochim Biophys Acta 1850: 1921–1929
  • Glaves JP, Primeau JO & Young HS (2015) Two-dimensional crystallization of the Ca2+-ATPase for electron crystallography. Meth Mol Biol (in press)
  • Herrmann M, Danielczak B, Textor M, Klement J & Keller S (2015) Modulating bilayer mechanical properties to promote the coupled folding and insertion of an integral membrane protein. Euro Biophys J 44: 503-512
  • Hofmann F, Belkacemi A & Flockerzi V (2015) Emerging alternative functions for the auxiliary subunits of the voltage-gated calcium channel. Curr Mol Pharmacol 8: 162-168
  • Hussein S, Dyte C, Zheng W, Yang J, Wang Q, Zhang F, Wu G, Cao Y, Tang J & Chen XZ (2015) Acid-induced activation of PKD2L1 channel in Xenopus oocytes and roles of Ca2+. Sci Rep 5: 15752
  • Lorenz A, Lorenz M, Vothknecht U, Niopek-Witz S, Neuhaus HE & Haferkamp I (2015) In vitro analyses of mitochondrial ATP/phosphate carriers from Arabidopsis thaliana revealed unexpected Ca2+-effects. BMC Plant Biol 15: 23
  • Melnyk A, Rieger H & Zimmermann R (2015) Co-chaperones of the mammalian Endoplasmic Reticulum. Subcel Biochem 78: 179-200
  • Miederer AM*, Alansary D, Schwär G,  Lee PH, Jung M, Helms V & Niemeyer BA (2015) A STIM2 splice variant negatively regulates store-operated calcium entry. Nat Commun 6: 6899, *Contributed equally
  • Panigrahi R, Whelan J & Vrielink A (2015) The design and structure of outer membrane receptors from mitochondria, plastids and peroxisomes. Structure (In Press) (DOI: dx.doi.org  /10.1016/j.str.2015.08.005)
  • Peleh V, Ramesh A & Herrmann JM (2015) Import of proteins into isolated yeast mitochondria. Meth Mol Biol 1270: 37-50
  • Ramesh A, Peleh V, Martinez-Caballero S, Wollweber F, Sommer F, van der Laan M, Schroda M, Alexander RT, Campo ML & Herrmann JM (2016) A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import. J Cell Biol 214: 417-431. Published August 8, 2016, doi:10.1083/jcb.201602074
  • Schorr S, Klein MC, Gamayun I, Melnyk A, Jung M, Schäuble N, Wang Q, Hemmis B, Bochen F, Greiner M, Lampel P, Urban SK, Haßdenteufel S, Dudek J, Chen XZ, Wagner R, Cavalié A & Zimmermann R (2015) Co-chaperone specificity in gating of the polypeptide conducting channel in the membrane of the human Endoplamic Reticulum. J Biol Chem 290: 18621-18635
  • Singaravelu R, O'Hara S, Jones DM, Chen R, Taylor NG, Srinivasan P, Quan C, Roy DG, Steenbergen RH, Kumar A, Lyn RK, Özcelik D, Rouleau Y, Nguyen MA, Rayner KJ, Hobman TC, Tyrrell DL, Russell RS & Pezacki JP (2015) MicroRNAs regulate the immunometabolic response to viral infection in the liver. Nat Chem Biol (doi: 10.1038/nchembio.1940)
  • Suzuki Y & Schmitt M (2015) Redox diversity in ERAD-mediated protein retrotranslocation from the endoplasmic reticulum: a complex puzzle. Biol Chem 396: 539–554
  • Textor M, Vargas C & Keller S (2015) Calorimetric quantification of linked equilibria in cyclodextrin/lipid/detergent mixtures for membrane-protein reconstitution. Methods 76: 183-193
  • Textor M & Keller S (2015) Calorimetric quantification of cyclodextrin-mediated detergent extraction for membrane-protein reconstitution. Method Enzymol (in press; DOI: 10.1016/bs.mie.2015.07.033)
  • Theparambil SM, Naoshin Z, Thyssen A & Deitmer JW (2015) Reversed electrogenic sodium-bicarbonate cotransport 1 is the major acid loader during the recovery from cytosolic alkalosis in mouse cortical astrocytes. J Physiol 593: 3533-3547
  • Valdebenito R, Ruminot I, Garrido-Gerter P, Fernández-Moncada I, Forero-Quintero L, Alegría K, Becker HM, Deitmer JW & Barros LF (2015) Targeting of astrocytic glucose metabolism by beta-hydroxybutyrate. J Cereb Blood Flow Metab, in press
  • Vargas C, Cuevas Arenas R, Frotscher E, Keller S (2015) Nanoparticle self-assembly in mixtures of phospholipids with styrene/maleic acid copolymers or fluorinated surfactants. Nanoscale (in press)
  • Vilas G, Krishnan D, Loganathan SK, Malhotra D, Liu L, Beggs MR, Gena P, Calamita G, Jung M, Zimmermann R, Tamma G, Casey JR & Alexander RT (2015) Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction. Mol Biol Cell 26: 1106-1118
  • Wang Q, Zheng W, Wang Z, Yang J, Hussein S, Tang J & Chen XZ (2015) Filamin-A increases the stability and plasma membrane expression of polycystin-2. PLoS One 10: e0123018
  • You J, Hou S, Malik-Soni N, Xu Z, Kumar A, Rachubinski RA, Frappier L & Hobman TC (2015) Flavivirus infection impairs peroxisome biogenesis and early anti-viral signaling. J Virol 2015 Sep 30. pii: JVI.01365-15

2014

2013

  • Bode M, Longen S, Morgan B, Peleh V, Dick TP, Bihlmaier K, Herrmann JM (2013) Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Antioxid Redox Signal. 18: 1597-1612
  • Bonar PT, Schneider HP, Becker HMDeitmer JWCasey JR (2013) Three-dimensional model for the human Cl-/HCO3- exchanger, AE1, by homology to the E. coli ClC protein. Journal of Molecular Biology 425: 2591-2608
  • Download pdf

    Picture of the AE1 homology model

    Movie of of the AE1 homology model

  • Deitmer JW & Becker HM (2013) Transport metabolons with carbonic anhydrases. Front. Physiol. 4: 291
  • Fischer M, Horn S, Belkacemi A, Kojer K, Petrungaro C, Habich M, Ali M, Küttner V, Bien M, Kauff F, Dengjel J, Herrmann JM & Riemer J (2013) Protein import and oxidative folding in the mitochondrial intermembrane space of intact mammalian cells. Mol Biol Cell 24: 2160-2170
  • Fischer M & Riemer J (2013) The mitochondrial disulfide relay system: roles in oxidative protein folding and beyond. Int J Cell Biol 2013: 742923
  • Gulaboski R, Bogeski I, Mirceski V, Saul S, Pasieka B, Haeri HH, Stefova M, Stanoeva JP, Mitrev S, Hoth M, Kappl R (2013) Hydroxylated derivatives of dimethoxy-1,4-benzoquinone as redox switchable earth-alkaline metal ligands and radical scavengers. Scientific Reports (doi 10.1038/srep0186)
  • Johnson N, Haßdenteufel S, Theis M, Paton AW, Paton JC, Zimmermann R, High S (2013) The signal sequence influences post-translational ER translocation at distinct stages. PLOS One 8: e75394
  • Klemens PAW, Patzke KDeitmer J, Spinner L, Le Hir R, Bellini C, Bedu M, Chardon F, Krapp A & Neuhaus EH (2013) Overexpression of the vacuolar sugar carrier AtSWEET16 modifies germination, growth and stress tolerance in Arabidopsis thaliana. Plant Physiology 163: 1338-1352
  • Klier M, Andes FT, Deitmer JW & Becker HM (2013) Intracellular and Extracellular Carbonic Anhydrases Cooperate Non-Enzymatically to Enhance Activity of Monocarboxylate Transporters. J. Biol. Chem. 289:2765-75
  • Linxweiler M, Schorr S, Jung M, Schäuble N, Linxweiler J, Langer F, Schäfers HJ, Cavalié A, Zimmermann R, Greiner M (2013)  Targeting cell migration and the Endoplasmic Reticulum stress response with calmodulin antagonists: A clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cell. BMC Cancer 13: 574
  • Pattu V, Halimani M, Ming M, Schirra C, Hahn U, Bzeih H, Chang HF, Weins L, Krause E & Rettig J (2013) In the crosshairs: investigating lytic granules by high-resolution microscopy and electrophysiology. Front Immunol 4: 411
  • Saul S, Stanisz H, Backes CS, Schwarz EC & Hoth M (2013) How ORAI and TRP channels interfere with each other: Interaction models and examples from the immune system and the skin. Eur J Pharmacol 739: 49-59
  • Schäuble N, Cavalié A, Zimmermann R & Jung M (2013) Interaction of Pseudomonas aeruginosa Exotoxin A with the human Sec61 complex suppresses passive calcium efflux from the Endoplasmic Reticulum. Channels 8: 76-83
  • Schneider HP, Alt MD, Klier M, Spiess A, Andes FT, Waheed A, Sly WS, Becker HM & Deitmer JW (2013) GPI-anchored carbonic anhydrase isoform IV displays extra- and intracellular catalytic activity both in cRNA-injected oocytes and in mouse neurons. Proc Natl Acad Sci USA 110: 1494-1499
  • Sierra-Valdez FJ, Forero-Quintero LS, Zapata-Morin PA, Costas M, Chavez-Reyes A & Ruiz-Suárez JC (2013) The influence of non-polar and polar molecules in mouse motile cell membranes and pure lipid bilayers. PloS One 8(4): e59364
  • Suzuki Y, Ali M, Fischer M & Riemer J (2013) Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria. Nat Commun 4: 2430

2012

    • Bode M, Longen S, Morgan B, Peleh V, Dick TP, Bihlmaier K & Herrmann JM (2012) Inaccurately assembled cytochrome c oxidase can lead to oxidative stress-induced growth arrest. Antioxid Redox Signal 18: 1597-1612
    • Chang HF, Bzeih H, Chitirala P, Ravichandran K, Sleiman M, Krause E, Hahn U, Pattu V & Rettig J (2017) Preparing the lethal hit: interplay between exo- and endocytic pathways in cytotoxic T lymphocytes. Cell Mol Life Sci. 74: 399-408. doi: 10.1007/s00018-016-2350-7. PMID: 27585956
    • Haßdenteufel S, Johnson N, Paton AW, Paton JC, High S & Zimmerman R (2018) Chaperone-mediated Sec61 channel gating during ER import of small precursor proteins overcomes Sec61 inhibitor-reinforced energy barrier. Cell Reports 23, 1373–1386
    • Hassler S, Lemke L, Jung B, Möhlmann T, Krüger F, Schumacher K, Espen L, Martinoia E, Neuhaus HE (2012) Lack of the Golgi phosphate transporter PHT4;6 causes strong developmental defects, constitutively activated disease resistance mechanisms and altered intracellular phosphate compartmentation in Arabidopsis. Plant J 72: 732-744
    • Hildenbeutel M, Theiss M, Geier M, Haferkamp I, Neuhaus HEHerrmann JMOtt M (2012) The membrane insertase Oxa1 is required for efficient import of carrier proteins into mitochondria. J Mol Biol 423: 590-599
    • Hirtz JJ, Braun N, Griesemer D, Hannes C, Janz K, Löhrke S, Müller B, Friauf E (2012) Synaptic refinement of an inhibitory topographic map in the auditory brainstem requires functional Cav1.3 calcium channels. J Neurosci 32: 14602-14616
    • Jakoby P, Schmidt E, Ruminot I, Gutierrez R, Barros LF & Deitmer JW (2012) Higher transport and metabolism of glucose in astrocytes compared to neurons: A multiphoton study of hippocampal and cerebellar tissue slices. Cereb Cortex (doi:10.1093/cercor/bhs309)
    • Johnson N, Vilardi, F, Lang S, Leznicki P, Zimmermann R & High S (2012) TRC-40 can deliver short secretory proteins to the Sec61 translocon. J Cell Sci (jcs.102608, doi:10.1242/jcs.102608)
    • Jurkovicova-Tarabova B, Griesemer D, Pirone A, Sinnegger-Brauns MJ, Striessnig J, Friauf E (2012) Repertoire of high voltage-activated Ca2+ channels in the lateral superior olive: functional analysis in wild-type, Cav1.3-/-, and Cav1.2DHP-/- mice. J Neurophysiol 108: 365-379
    • Keil M, Bareth B, Woellhaf MW, Peleh V, Prestele M, Rehling P, Herrmann JM (2012) Oxa1-ribosome complexes coordinate the assembly of cytochrome c oxidase in mitochondria. J Biol Chem. 287: 34484-34493
    • Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Haßdenteufel S, Tatzelt J, Kreutzer B, Edelmann L, Krause E, Rettig J, Somlo S, Zimmermann R & Dudek J (2012) Different effects of Sec61a-, Sec62 and Sec63-depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci 125: 1958-1969
    • Linxweiler M, Linxweiler J, Barth M, Benedix J, Jung V, Kim YJ, Bohle R, Zimmermann R & Greiner M (2012) Sec62 bridges the gap from 3q amplification to molecular cell biology in Non-Small Cell Lung Cancer.  Am J Pathol 180: 473-483
    • Pfeffer S, Brandt F, Hrabe T, Lang S, Eibauer M, Zimmermann R & Förster F (2012) Structure and 3D Arrangement of Endoplasmic Reticulum Membrane-Associated Ribosomes. Structure (doi:10.1016/j.str.2012.06.010)
    • Saab AS, Neumeyer A, Jahn HM, Cupido A, Simek AAM, Boele HJ, Scheller A, Le Meur K, Götz M, Monyer H, Sprengel R, Rubio ME, Deitmer JW, Zeeuw de C & Kirchhoff F (2012) Bergmann glial AMPA receptors are required for fine motor coordination. Science 337: 749-753
    • Satheesh SV, Bartels K, Rüttiger L, Zuccotti A, Schönig K, Friauf E, Knipper M, Bartsch D, Nothwang HG (2012) Retrocochlear function of the peripheral deafness gene Cacna1d. Hum Mol Genet 21: 3896-3909
    • Schäuble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan Ö, Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavalié A & Zimmermann R (2012) BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. EMBO Journal 31: 3282-3296
    • Schweiger R, Müller NC, Schmitt MJ, Soll J & Schwenkert R (2012) AtTPR7 is a chaperone docking protein of the Sec translocon in Arabidopsis. J Cell Sci (doi: 10.1242/​jcs.111054)
    • Stridh M, Alt M, Wittmann S, Heidtmann H, Aggarwal A, Riederer B, Seidler U, Wennemuth G, McKenna R, Deitmer JW & Becker HM (2012) Lactate fluxes in astrocytes enhanced by a non-catalytic action of carbonic anhydrase II. J Physiol 590: 2333-2351
    • Witz S, Jung B, Fürst S & Möhlmann T (2012) De novo pyrimidine nucleotide synthesis mainly locates outside of plastids, but a novel nucleobase importer provides substrates for the essential salvage pathway. Plant Cell 24: 1549-1559