Dysfunction of membrane proteins and protein compartmentalization can seriously compromise normal functioning of cells and organisms, and has been implicated in detrimental diseases such as immune-mediated diseases, deafness, cystic fibrosis, cancer, cardiovascular dysfunction, and Alzheimer's. Moreover, altered activity of many membrane proteins causes dramatic effects on developmental and cellular adaptation processes in animal and plant cells.

We will investigate selected membrane transporters, protein targeting and translocation across biological membranes, protein folding, and the role of membrane proteins in developmental processes and diseases.

Our mission consists the following:

(i) to generate fundamental information about the control of abundance and activity of membrane proteins,

(ii) to understand their biochemical and functional properties, and 

(iii) to set the protein(s) of interest into the physiological context under normal and pathological conditions. 

To achieve these goals, the IRTG will offer an inimitable access to selected powerful experimental model systems like various primary human cell types, mouse models, yeast or Arabidopsis and provides a broad array of sophisticated experimental approaches.